Experimental Pharmacology Instruments

1. Digital Thermometer

• Description: A precise instrument used to measure temperature in various experimental settings.
• Usage:
  1. Preparation: Ensure the thermometer is clean and has functional batteries.
  2. Measurement: Place the probe in the desired location (e.g., inside a solution or on the skin of an animal subject).
  3. Reading: Wait for the digital display to stabilize and record the temperature.
• Maintenance:
  • Clean the probe with alcohol wipes after each use.
  • Replace batteries when the display dims or shows a low battery indicator.

2. Rats-Rod Apparatus (6-channel)

• Description: An apparatus designed to evaluate motor coordination and balance in rodents by measuring the time they can stay on a rotating rod.
• Usage:
  1. Setup: Place the rodent on the rotating rod.
  2. Operation: Start the rotation at a set speed and observe the rodent’s performance.
  3. Recording: Note the time the rodent remains on the rod before falling.
• Maintenance:
  • Clean the rod and surrounding area to ensure hygiene.
  • Check the rotation mechanism for smooth operation and lubricate if necessary.

3. Electroconvulsometer

• Description: A device used to induce and measure convulsions in animal models, typically for studying the effects of anticonvulsant drugs.
• Usage:
  1. Preparation: Attach electrodes to the subject (e.g., a rodent) following safety protocols.
  2. Induction: Set the desired parameters (e.g., voltage, duration) and initiate the convulsion.
  3. Measurement: Observe and record the convulsion parameters.
• Maintenance:
  • Regularly inspect electrodes and wires for wear and tear.
  • Clean the electrodes after each use to prevent contamination.

4. Analgesiometer

• Description: An instrument used to assess pain response in experimental subjects, often by applying a controlled stimulus and measuring the reaction time.
• Usage:
  1. Setup: Position the subject and ensure it is comfortable.
  2. Application: Apply the stimulus (e.g., heat, pressure) and start the timer.
  3. Recording: Measure the time taken for the subject to respond to the stimulus.
• Maintenance:
  • Calibrate the device regularly to ensure accurate measurements.
  • Clean the contact points after each use.

5. Sherrington Recording Drum

• Description: A rotating drum used to record physiological responses, such as muscle contractions, on a moving paper surface.
• Usage:
  1. Preparation: Attach the recording pen to the drum and connect it to the subject.
  2. Recording: Start the drum rotation and observe the pen tracing the physiological response on the paper.
  3. Analysis: Analyze the recorded data for research purposes.
• Maintenance:
  • Ensure the drum rotates smoothly and the pen is functional.
  • Replace the paper regularly and keep the drum clean.

6. Rotating Drum

• Description: Similar to the Sherrington drum, used for recording various physiological responses.
• Usage:
  1. Setup: Connect the drum to the subject and ensure all connections are secure.
  2. Operation: Start the drum and monitor the recording process.
  3. Data Collection: Collect and analyze the recorded data.
• Maintenance:
  • Keep the drum and recording mechanism clean.
  • Check for any mechanical issues and address them promptly.

7. Weighing Machine

• Description: A precise scale used to measure the weight of subjects or substances in experimental settings.
• Usage:
  1. Preparation: Ensure the scale is calibrated and placed on a stable surface.
  2. Measurement: Place the item or subject on the scale and read the measurement.
  3. Recording: Record the weight for further analysis.
• Maintenance:
  • Calibrate the scale regularly to maintain accuracy.
  • Clean the weighing surface after each use to prevent contamination.